What is lymphocyte immunization therapy ?

LIT is the first immunomodulatory treatment that was used, to treat unexplained RM patients. It involves the immunization of the prospective mother with allogenic mononuclear cells, mainly lymphocytes.

LIT is performed with paternal and donor lymphocytes. Lymphocytes are the most important cells in the immune system and play an important role in rejection response against immunologically different substrates. Use of lymphocytes has been suggested to modulate the immune response against immunologically different fetuses in the mother’s body.