What Does Research Suggest About Unexplained Infertility and Egg Quality?
August 1, 2025
August 1, 2025

For many couples in Mumbai, the fertility journey does not follow a straightforward path. Delayed parenthood, hormonal imbalance, and ovulatory disorders have become some of the city's biggest contributors to infertility, driven by high-pressure work culture, long commute times, and late family planning. A 2026 study from Mumbai’s Cama and Albless Hospital found that many couples waited 5–10 years before seeking fertility treatment, with ovulatory dysfunction emerging as a major cause, particularly among urban professionals aged 31–35.
By the time many couples begin trying seriously for pregnancy, they are often already facing repeated IVF failures, implantation issues, or pregnancy losses that standard investigations cannot fully explain. When the usual answers stop working, the question shifts from “what treatment should we try next” to “is there something we are missing entirely?”
That is precisely the gap that ICPRM is built to address. As a centre focused specifically on the immunological dimension of fertility, we work with couples who have already been through conventional treatment and are still looking for answers. The infertility specialists in Mumbai at ICPRM, Dr. Mohan Raut and Dr. Mugdha Raut, bring over 35 years each of combined clinical experience in obstetrics, gynecology, and reproductive immunology to every case they evaluate.
A pregnancy requires more than a healthy egg and sperm. The maternal immune system must also respond in a very specific way, essentially recognizing the embryo not as foreign tissue but as something to protect and support. In some cases, this recognition does not happen the way it should. The immune system may respond in a way that interferes with implantation, or that cannot sustain a pregnancy once it begins.
These immune-related disruptions do not always show up on routine fertility panels, which is why many couples are left with a diagnosis of "unexplained" despite thorough testing.
This is where reproductive immunology becomes relevant. When IVF has been attempted multiple times with good-quality embryos and implantation continues to fail, or when pregnancies repeatedly end in early loss without a structural or genetic explanation, the immune system warrants a closer look. Understanding this connection often changes how couples and their doctors think about what the next step should actually be.
ICPRM is located in Santacruz East, in the Vakola area, near St. Charles School and behind Vakola Masjid, close to the Western Express Highway. For patients traveling from Bandra, BKC, Andheri, Kurla, or Kalina, the location is easily accessible. Those coming from Navi Mumbai or Thane can reach the centre without significant difficulty, and for couples flying in from other cities, the proximity to Mumbai Airport makes our centre an efficient option for those seeking specialized care outside their home city.
Our centre does not function as a general fertility clinic. Every aspect of ICPRM's practice, from investigations to treatment, is oriented around reproductive immunology, recurrent IVF failure, repeated miscarriages, and unexplained infertility. The primary treatment offered is ImmuLIT®, a patented Lymphocyte Immunization Therapy procedure. For patients who prefer to begin remotely, online consultation is available before any in-person visit is required.
The patients who come to us have typically already done a great deal. They have undergone investigations, tried cycles, and received treatment from qualified fertility specialists. What brings them here is not a lack of effort but a lack of answers. Our approach is built around one question: could immune-related factors be contributing to repeated failure?
That question, when pursued properly, often opens a path that earlier investigations did not. This is why we’re the preferred reproductive immunology center in Mumbai. We evaluate each case through a reproductive immunology lens before recommending any course of treatment.
Some couples undergo two, three, or more IVF cycles with embryos that are chromosomally normal and structurally viable, yet implantation does not occur. When this pattern repeats, it raises the possibility that the issue is not with the embryo but with how the uterine environment is responding to it.
Repeated pregnancy loss is one of the most difficult experiences a couple can go through, particularly when every standard report comes back within normal range. Structural assessments, genetic panels, and hormonal profiles may all appear unremarkable, and yet the pregnancies continue to fail.
Being told that all reports are normal but still being unable to conceive or sustain a pregnancy is its own kind of frustration. The label of unexplained infertility is not inaccurate, but it is incomplete. It reflects the limits of conventional testing more than it reflects an absence of underlying cause.
The treatment process at ICPRM is designed to be clear, organized, and as straightforward as possible for couples who have already spent considerable time and energy on fertility treatment. Here is how the process typically unfolds:
Parenthood: The goal of the entire process is to give couples a clearer and more supported path toward a successful pregnancy. For many, ImmuLIT® forms one part of a broader fertility plan rather than a standalone intervention.

M.D.D.G.O, FCRI
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist

M.D., D.G.O., F.C.R.I.(ASRI)
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist
Mumbai has no shortage of fertility clinics. What it has fewer of are centres that approach repeated failure specifically through the lens of reproductive immunology. Patients who come to us are typically not first-time fertility patients. They arrive having already tried other treatments and looking for a different kind of evaluation. The best infertility doctors in Mumbai for this specific patient group are those who understand not just fertility, but the immune system's role in it.
Our ImmuLIT® procedure, which sits at the centre of the practice's clinical work, is associated with an approximately 80% success rate in appropriately selected cases. That figure is not a general fertility promise; it reflects outcomes among couples whose repeated failures had an identifiable immunological component and who underwent the full treatment process.
The centre's location in Santacruz East, its availability for online consultation, and the single-sitting nature of the ImmuLIT® procedure make it an easily accessible option for couples across the city and from outside Mumbai who are seeking unexplained infertility experts in Mumbai and immune-focused fertility care.
1.What is reproductive immunology in fertility treatment?
Reproductive immunology is the study of how the immune system interacts with pregnancy. In some couples facing repeated IVF failure or recurrent miscarriages, the immune system may be responding in a way that prevents successful implantation or the continuation of a pregnancy. Reproductive immunology investigates these immune factors and looks at whether they can be addressed through targeted treatment.
2.What is LIT or ImmuLIT treatment?
Lymphocyte Immunization Therapy, offered at ICPRM as the patented ImmuLIT procedure, is a form of immunotherapy used in the treatment of recurrent miscarriage, recurrent IVF failure, and unexplained infertility. The procedure involves introducing specific immune signals to help the maternal immune system respond more appropriately to the embryo. At ICPRM, it is completed in a single sitting lasting approximately three hours.
3.Who may benefit from ImmuLIT treatment?
ImmuLIT is primarily considered for couples who have experienced repeated IVF failures despite healthy embryos, those who have had two or more unexplained miscarriages, or couples diagnosed with unexplained infertility where standard investigations have not identified a cause. The doctors at ICPRM assess each case individually to determine whether an immunological evaluation and ImmuLIT are appropriate.
4.Can ICPRM help with repeated miscarriages?
Yes. Recurrent miscarriage is one of the core conditions ICPRM specializes in. When standard testing does not identify a structural, hormonal, or genetic cause for repeated pregnancy loss, immune-related factors may be a contributing element. ICPRM investigates these factors and, where relevant, offers ImmuLIT as a treatment pathway.
5.Is online consultation available?
Yes. Couples can begin the process with an online consultation, during which the doctors review the couple's medical history and investigation reports and assess whether ICPRM's approach is relevant to their case. This makes it possible to get a specialist evaluation without an immediate in-person visit, which is particularly useful for couples traveling from outside Mumbai.
6.How long does the ImmuLIT procedure take?
The ImmuLIT procedure is completed in a single outpatient sitting that typically takes around three hours. It does not require surgical intervention or hospital admission, which makes it a manageable process for couples juggling other commitments.
7.Where is ICPRM located in Mumbai?
ICPRM is located at Dr. Raut's Women's Hospital, 1st Floor, Karlton Apartment, Akola Village Road, near St. Charles School, behind Vakola Masjid, Vakola, Santacruz East, Mumbai 400055. The centre is accessible from Bandra, BKC, Andheri, Kurla, Navi Mumbai, and Thane, and is close to the Western Express Highway and Santacruz Railway Station.
If repeated IVF failures, unexplained miscarriages, or inconclusive fertility reports have left you without a clear path forward, ICPRM Mumbai is where that changes. Book a consultation today!