What Does Research Suggest About Unexplained Infertility and Egg Quality?
August 1, 2025
August 1, 2025

India is home to approximately 27.5 million couples facing infertility, with urban areas reporting rates as high as 15–20%. Across the country, delayed parenthood, chronic stress, sedentary lifestyles, obesity, and hormonal disorders like PCOS are increasingly contributing to fertility challenges. Research estimates that nearly 1 in 5 Indian women may be affected by PCOS, making it one of the country’s biggest drivers of ovulatory dysfunction and unexplained infertility.
Many couples seeking fertility care today have already undergone IVF cycles and standard investigations, yet still remain without clear answers. ICPRM focuses specifically on this category of patients through our six centres across Mumbai, Pune, Nagpur, Hyderabad, Bengaluru, and Delhi, investigating the immunological causes of repeated fertility failure through the patented ImmuLIT® procedure.
What sets this evaluation apart is not the technology but the focus. Most fertility clinics are equipped to handle a broad range of reproductive conditions. ICPRM is designed for a narrower and more specific clinical question: when everything else has been ruled out, could the immune system be the missing piece?
Standard fertility investigations cover ovarian reserve, sperm quality, uterine structure, hormone levels, and in some cases genetic factors, but they do not routinely examine the immune system's role in implantation. Research suggests that immune-related infertility affects roughly 5 to 20% of couples who are unable to conceive, and the actual numbers may be higher because immune factors are not part of most standard fertility checkups.
When the immune system does not respond appropriately to an embryo, it can interfere with implantation or prevent a pregnancy from continuing past its earliest stages, often without any visible abnormality in routine reports. Reproductive immunology investigates this specific layer of fertility, looking at immune factors that conventional assessments are not designed to detect.
ICPRM operates across six cities and functions differently from a general fertility clinic. The centre focuses on a defined set of conditions where immune-related factors may be contributing to treatment failure: recurrent IVF failure, repeated miscarriages, and unexplained infertility. Every patient who comes to us has typically already been through conventional fertility care, and the evaluation here picks up where that care left off.
The centre's primary treatment, ImmuLIT®, is a patented Lymphocyte Immunization Therapy. Studies show that LIT therapy has been associated with a notable increase of 8-10% in the probability of live birth in appropriately evaluated cases, and in ICPRM's clinical experience, the procedure is associated with approximately an 80% success rate among selected recurrent miscarriage and recurrent IVF failure cases.
The couples who consult ICPRM across India share a recognizable pattern: they have undergone fertility treatment, followed clinical advice carefully, and still find themselves in the same position after each cycle. The question we begin with is not which treatment to try next but whether the immune dimension of their case has ever been properly assessed.
Across all six centres, the clinical approach remains consistent: a structured reproductive immunology evaluation followed by ImmuLIT® where indicated, and immunomodulatory support through the subsequent fertility attempt. The process is designed to complement whatever fertility treatment the couple pursues with their existing specialists.
Recurrent pregnancy loss can occur even when structural, hormonal, and genetic investigations return normal results. Recurrent pregnancy loss treatment in India at ICPRM involves an immune-focused evaluation designed to identify whether the body's immune response may be interfering with early pregnancy continuation, a factor that standard miscarriage investigations do not routinely assess.
When IVF fails repeatedly despite good embryo quality, the investigation needs to expand beyond standard fertility protocols. We evaluate whether immune-related factors in the uterine environment may be affecting implantation, offering couples a more targeted clinical explanation for why transfer cycles that should have worked have not.
In 10-15% of infertility cases in India, no specific cause is identified despite extensive testing. For many of these couples, the label of unexplained infertility reflects the limits of conventional investigation rather than the true absence of a cause. Our reproductive immunology evaluation investigates immune factors that fall outside the standard fertility workup.
The treatment process at ICPRM is structured to be clear and manageable, particularly for couples who have already been through demanding fertility treatment journeys. Regardless of which city a patient consults from, the pathway follows the same defined stages.

M.D.D.G.O, FCRI
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist

M.D., D.G.O., F.C.R.I.(ASRI)
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist
Couples consulting ICPRM from cities across India share a common clinical profile: they have been through fertility treatment, received conventional care, and are still without a satisfying explanation for why outcomes have not changed. The best infertility doctors in India for this patient group are those who can evaluate the immune dimension of fertility failure rather than repeat the same clinical pathway.
Our presence across six cities means specialist reproductive immunology evaluation is accessible without long-distance travel for most patients. The process begins with an online consultation, making the initial evaluation accessible from anywhere in the country. For couples outside these cities or based abroad, the single-sitting nature of ImmuLIT® makes it practical to travel for treatment without an extended stay.
1.Does ICPRM offer IVF treatment directly?
No. ICPRM is not a general IVF clinic. The centre focuses specifically on reproductive immunology evaluation and ImmuLIT treatment for couples experiencing recurrent IVF failure, repeated miscarriages, and unexplained infertility. Couples typically continue IVF with their existing fertility specialist while incorporating ICPRM's immunological treatment protocol.
2. How does ICPRM evaluate whether immune factors are contributing to infertility?
ICPRM conducts targeted immunological investigations that go beyond standard fertility panels. These tests assess specific immune markers that may be interfering with implantation or early pregnancy continuation, and the findings determine whether ImmuLIT is an appropriate next step.
3.Can couples from smaller cities or rural areas consult ICPRM?
Yes. The initial consultation can be conducted online, which means couples from anywhere in India can begin the evaluation remotely. The ImmuLIT procedure is completed in a single outpatient sitting at one of ICPRM's six centres.
4.Is ImmuLIT a replacement for IVF or other fertility treatments?
No. ImmuLIT addresses a specific immune-related dimension of fertility failure and is recommended alongside the couple's existing fertility treatment plan rather than in place of it.
5.How soon after the ImmuLIT procedure can a couple attempt IVF or natural conception?
Timing is guided by the doctors based on each couple's immunological response and overall fertility plan. Follow-up after the procedure is an important part of the process, and specific guidance is provided before the next fertility attempt begins.
6.Are NRI couples or those based outside India able to consult ICPRM?
Yes. The online consultation model makes the initial evaluation accessible internationally, and the single-sitting ImmuLIT procedure allows couples to travel to one of ICPRM's six centres without requiring an extended stay.
7.What is the difference between unexplained infertility and immune-related infertility?
Unexplained infertility is a clinical label given when standard investigations do not identify a specific cause. Immune-related infertility is a more specific finding where the immune system's response to the embryo is identified as a contributing factor. In many unexplained cases, immune factors may be present but have simply not been investigated. ICPRM's evaluation looks specifically at whether this is the case.
If repeated IVF failures, unexplained miscarriages, or implantation issues continue without answers, ICPRM helps uncover the immune-related causes standard fertility care often misses. Book a consultation today!