What Does Research Suggest About Unexplained Infertility and Egg Quality?
September 3, 2025
September 3, 2025

Nagpur sits at the geographical heart of India, and its healthcare landscape, while growing, still sees many women arrive at fertility care late, after years of untreated gynecological conditions or recurrent infections that have quietly compounded into fertility challenges. Reproductive tract infections, pelvic inflammatory disease, and chronic untreated gynecological conditions are among the more common underlying factors seen in women seeking fertility help across central India.
The difficulty is that many of these conditions do not announce themselves loudly. By the time a woman seeks care for an inability to conceive, the underlying gynecological issue may have been present for years, sometimes silently damaging fallopian tube function, disrupting the uterine environment, or triggering persistent low-grade immune responses that interfere with implantation.
ICPRM, led by Dr. Mugdha Raut, a female reproductive immunologist in Nagpur, has been built around exactly this kind of complex, underserved fertility problem. Our centre evaluates the immune dimension of fertility, including how past infections and inflammatory responses may still be affecting a woman's ability to conceive or sustain a pregnancy, and provides a treatment pathway that goes far beyond what routine fertility care typically offers.
Infections and chronic gynecological conditions can leave a lasting mark on the immune environment of the reproductive system. Even after an infection resolves, the immune response it triggers can remain dysregulated, creating an environment where embryo implantation is compromised. The uterus may respond to an embryo as it would to a pathogen, rejecting it rather than allowing it to establish. This immune over-reactivity is a recognized cause of recurrent miscarriage and repeated implantation failure.
What makes this particularly challenging is that standard fertility workups rarely assess this dimension. Routine semen analyses, ovulation tracking, and hormonal panels do not reveal immune dysregulation. A patient may be told her reports are normal while an underlying immune-mediated implantation barrier remains undetected. Reproductive immunology exists precisely to find and address this gap.
At ICPRM, we begin where routine fertility evaluations stop. Dr. Mugdha Raut conducts a detailed review of each patient's gynecological and fertility history, combined with a targeted immunological assessment designed to identify whether the immune system is obstructing implantation. For patients in Nagpur who have had prior infections, repeated pregnancy loss, or unexplained infertility, this evaluation is often the first time someone has looked at the immune picture in depth.
Our ImmuLIT® treatment, based on Lymphocyte Immunization Therapy, is administered once immune factors have been identified and assessed. It is designed to help the body build tolerance for a pregnancy, correcting the immune dysfunction that may be preventing conception or causing early losses. The procedure is completed in a single sitting, and patients are guided carefully through each stage.
The process at our centre is straightforward and structured:
Dr. Mugdha Raut is a Gynaecologist and Clinical Reproductive Immunologist holding M.D., D.G.O., and F.C.R.I. (ASRI) qualifications. Her clinical career spans over 35 years, covering obstetrics, gynecology, and the specialized field of reproductive immunology. She is one of India's most experienced practitioners in managing cases of recurrent miscarriage, implantation failure, and unexplained infertility where immune factors are involved.
As Co-founder and Partner at ICPRM, Dr. Raut's clinical philosophy is built on personalized care. She understands that patients arriving with complex, unresolved fertility histories need more than a standard protocol. Instead, they need a clinician who will investigate deeply, explain clearly, and build a treatment plan around their specific situation. Her experience and focused expertise have made her a sought-after specialist for patients across central India.
For many women in Nagpur, ICPRM represents access to a level of reproductive immunology expertise that is not available through local fertility centres. Patients who have been through rounds of treatment without answers, or who have been told their reports are normal while pregnancies continue to fail, find a different kind of clinical investigation at our centre. We also offer online consultations for those who want to connect with Dr. Raut before travelling for an in-person evaluation.
Our Nagpur consultations are conducted at Cardion Hospital, Opposite Dinanath High School, Tikekar Road, Dhantoli, Nagpur 440012. If you have been living with unexplained infertility or repeated pregnancy loss, we encourage you to reach out. There may well be answers that have not yet been explored.
1. Can a past reproductive tract infection affect my fertility now?
Yes. Infections like pelvic inflammatory disease can leave lasting changes in the uterine environment and trigger immune responses that interfere with implantation. Even after the infection has resolved, its effects on fertility can persist.
2. I have been told my reports are normal but I cannot conceive. What should I do?
Normal routine reports do not rule out immune-related fertility issues. At ICPRM, we conduct specialized immunological testing that standard workups do not include. This often reveals patterns that explain why conception or pregnancy maintenance is failing.
3. What is pelvic inflammatory disease and how does it affect fertility?
Pelvic inflammatory disease (PID) is an infection of the female reproductive organs. If untreated or delayed in treatment, it can cause scarring, tubal damage, and immune dysregulation, all of which can impair fertility.
4. Does ICPRM see patients only from Nagpur?
No. We see patients from across central India and beyond. Online consultations allow patients from any location to connect with Dr. Raut before arranging an in-person visit.
5. How is ImmuLIT different from other immunotherapy treatments?
ImmuLIT is ICPRM's own patented and branded process, based on Lymphocyte Immunization Therapy. It is specifically designed and refined for reproductive immune challenges, not a general immunotherapy adapted for fertility use.
6. Is ICPRM suitable for women who have never conceived before? Yes. We see both primary infertility (never conceived) and secondary infertility (unable to conceive again after a previous pregnancy). Immune factors can be relevant in both situations.
7. What should I bring to my first consultation at the Nagpur centre? It helps to bring any previous fertility investigation reports, records of past gynecological treatments or infections, IVF cycle summaries if applicable, and a timeline of your fertility history. The more information Dr. Raut has, the more targeted the evaluation can be.

M.D.D.G.O, FCRI
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist

M.D., D.G.O., F.C.R.I.(ASRI)
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist