What Does Research Suggest About Unexplained Infertility and Egg Quality?
September 3, 2025
September 3, 2025

Mumbai moves fast. Careers, commitments, and city life often take priority, and for many couples, family planning quietly gets pushed to later. By the time they are ready, some women find that the delay has come with its own fertility challenges: irregular cycles, poor egg quality, or a diagnosis of ovulatory dysfunction. Studies from fertility centres across Mumbai have noted a rise in ovulatory disorders and declining ovarian reserve among women in their early thirties, a concern that is becoming increasingly common across the city.
For many of these women, the standard fertility workup comes back unremarkable. Hormones look acceptable. Scans seem normal. And yet conception remains elusive, or pregnancies end before they can progress. This gap between "normal" reports and unexplained infertility is exactly where reproductive immunology begins to offer answers that conventional testing cannot.
This is where ICPRM and Dr. Mugdha Raut come in. Our centre is focused specifically on immune-mediated fertility challenges, offering specialized evaluation and treatment for women who have not found answers through routine IVF or gynecological care. If you are looking for a knowledgeable and experienced female infertility specialist in Mumbai, Dr. Raut brings over 35 years of clinical experience in obstetrics, gynecology, and reproductive immunology to every patient she sees.
Most fertility evaluations focus on hormones, egg quality, sperm parameters, and uterine structure. What they often do not assess is how the immune system is responding during the critical window of implantation. For a pregnancy to establish itself, the body must temporarily tolerate the embryo, which is genetically different from the mother, rather than attack it. When this immune tolerance fails, the embryo may not implant, or may implant and then be lost early, even when everything else looks fine.
This is a recognized driver of recurrent miscarriage, recurrent implantation failure, and repeated IVF failure. In some cases, women with unexplained infertility have an immune system that is simply not adapting the way it should during the early stages of pregnancy. Standard fertility workups are not designed to catch this. A targeted reproductive immunology evaluation can identify these patterns and guide treatment accordingly.
At ICPRM, we see a specific kind of patient. Someone who has often already tried IVF, gone through multiple cycles, or experienced pregnancy losses with no clear explanation. Dr. Mugdha Raut leads our immune-focused fertility evaluation, which goes beyond what routine fertility centres typically investigate. The focus is on identifying whether the immune system is playing a role in why pregnancies are not progressing or not happening at all.
Our core treatment, ImmuLIT® (Lymphocyte Immunization Therapy), is a patented procedure based on established immunotherapy principles. It is designed to help the body build appropriate immune tolerance for a pregnancy to succeed. Patients come to us after years of unanswered questions, and our approach gives them a structured, evidence-based path forward that addresses the immune factors most fertility centres overlook.
Here is how the process works at our centre:
Dr. Mugdha Raut is a Gynaecologist and Clinical Reproductive Immunologist with the qualifications M.D., D.G.O., and F.C.R.I. (ASRI). As the best female infertility doctor in Mumbai, she has dedicated a significant part of her career to understanding why some women face repeated pregnancy failures despite having otherwise normal reports. Her work covers recurrent miscarriage, recurrent implantation failure, IVF failure, and unexplained infertility.
As Co-founder and Partner at ICPRM, Dr. Raut's approach is deeply patient-centric. She integrates advanced diagnostics with personalized immunotherapy planning, ensuring that each patient receives a treatment plan built around their specific immune profile. Her clinical reputation has made our centre a destination for patients from across the city and beyond.
Mumbai already has access to a wide range of IVF clinics and fertility hospitals. But for women dealing with recurrent IVF failure or unexplained infertility, the standard IVF pathway often does not address the root cause. Patients come to ICPRM specifically because we offer something different: a reproductive immunology evaluation that goes deeper than conventional fertility workups. Online consultations are also available for patients who need to connect with us before visiting in person.
Our Mumbai centre is located at Dr. Raut's Women's Hospital, 1st Floor, Karlton Appt, Akola Village Road, near St. Charles School, behind Vakola Masjid, Vakola, Santacruz-East, Mumbai 400055. Whether you are navigating unexplained infertility, repeated pregnancy loss, or failed IVF cycles, we are here to help you find the clarity and the care you need.
1. What makes ICPRM different from a regular IVF clinic in Mumbai?
ICPRM is a specialized reproductive immunology centre, not a routine IVF clinic. We focus specifically on immune-related causes of infertility, recurrent miscarriage, and implantation failure, areas that standard IVF workups often do not evaluate.
2. How do I know if my infertility has an immune cause?
If you have experienced repeated failed IVF cycles, multiple miscarriages, or unexplained infertility despite normal test results, immune factors may be involved. Our evaluation is designed to identify these patterns.
3. Is ImmuLIT safe?
Yes. ImmuLIT is based on Lymphocyte Immunization Therapy, a clinically established approach. The procedure is administered under supervised conditions and has a well-documented safety profile.
4. Can I consult Dr. Mugdha Raut online before visiting the Mumbai centre?
Yes. We offer online consultations so patients can discuss their history and understand whether an in-person visit and ImmuLIT evaluation is appropriate for their situation.
5. I have had two failed IVF cycles with normal embryos. Can ICPRM help?
This is one of the most common presentations we see. Repeated implantation failure with good quality embryos is often linked to immune tolerance issues, which is precisely what our evaluation and ImmuLIT treatment addresses.
6. Does ICPRM treat secondary infertility?
Yes. Secondary infertility, difficulty conceiving or maintaining a pregnancy after a previous successful one, can also have immune components. We evaluate and treat this at our centre.
7. How long does the ImmuLIT procedure take?
The ImmuLIT procedure is completed in a single sitting of approximately three hours. You do not need to be admitted to the hospital for it.

M.D.D.G.O, FCRI
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist

M.D., D.G.O., F.C.R.I.(ASRI)
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist