What Does Research Suggest About Unexplained Infertility and Egg Quality?
September 3, 2025
September 3, 2025

India is in the middle of a quiet fertility crisis. An estimated one in five Indian women may have PCOS, and urban lifestyle patterns, delayed family planning, sedentary work, poor sleep, and chronic stress are compounding hormonal and ovulatory dysfunction at a scale that the country's fertility care system is still catching up with. Unexplained infertility, recurrent implantation failure, and pregnancy loss are being reported with increasing frequency by fertility specialists across the country's major cities.
What unites many of these cases is a shared clinical frustration: investigations are run, IVF is attempted, and yet pregnancies do not happen or do not continue. The standard workup does not always find the answer, and patients are left cycling through treatments without resolution. For women seeking the best female infertility doctor in India who looks at fertility from a different clinical angle, reproductive immunology is increasingly becoming the answer.
ICPRM, led by Dr. Mugdha Raut, is one of India's few centres dedicated exclusively to immune-mediated fertility challenges. Operating across Mumbai, Hyderabad, Nagpur, Pune, Bengaluru, and Delhi, we offer patients across the country access to specialized reproductive immunology care, including our patented ImmuLIT treatment, that is rarely available through conventional fertility clinics.
The immune system is deeply involved in reproduction. For a pregnancy to succeed, the immune system must recognize and protect the embryo rather than reject it. In India's urban population, factors like PCOS-related inflammation, metabolic dysregulation, chronic stress, and environmental exposures can all interfere with this immune tolerance process. The result is often a pattern of unexplained infertility, recurrent early miscarriage, or repeated failure to implant, even when embryo quality and hormonal profiles appear acceptable.
The difficulty is that these immune mechanisms are not captured by standard fertility investigations. A woman can have normal AMH, clear tubes, a regular cycle, and still be experiencing immune-mediated implantation failure. This is the diagnostic gap that reproductive immunology was developed to address, and it is where our evaluation and treatment at ICPRM begins.
Patients come to ICPRM from across India, often after spending years in the conventional fertility system. Dr. Mugdha Raut's approach starts with a comprehensive immune-focused evaluation. This is not a supplementary add-on to standard fertility care; it is an entirely different clinical investigation built around a women's fertility specialist in India who has spent decades understanding the immune causes of pregnancy failure.
Our treatment, ImmuLIT® (Lymphocyte Immunization Therapy), is ICPRM's own patented process, developed and refined specifically for reproductive immune challenges. It is applied once the immune evaluation identifies the relevant dysfunction, and is tailored to each patient's immune profile and fertility history. The goal is to create the biological conditions needed for a pregnancy to establish and progress.
Wherever you are in India, our treatment process at ICPRM follows the same careful structure:
Dr. Mugdha Raut is widely considered one of India's foremost authorities on clinical reproductive immunology. With over 35 years of experience across obstetrics, gynecology, and immune-mediated fertility care, she has built a practice focused entirely on the cases that remain unresolved after conventional treatment. As the best female infertility doctor in India, she has worked with patients from across the country, developing the clinical expertise and treatment protocols that underpin ICPRM.
Her work is evidence-based, her approach is personalized, and her clinical communication is clear and patient-centred. Dr. Raut co-founded ICPRM to give India's fertility patients access to a standard of immune-focused care that was simply not available through the conventional fertility system. Today, that centre operates across six cities, and online consultations extend our reach even further.
India's fertility care landscape has grown significantly, but it remains largely built around the standard IVF model. For the growing number of patients with unexplained infertility, recurrent miscarriage, or repeated IVF failure, that model often does not go far enough. ICPRM was designed for this gap, offering a reproductive immunology evaluation and ImmuLIT treatment at six locations across the country. Online consultations make it easy for patients in any city to begin their assessment with Dr. Raut before travelling to their nearest centre.
ICPRM currently operates in Mumbai, Hyderabad, Nagpur, Pune, Bengaluru, and Delhi. Wherever you are in India, if you have been through fertility treatment without resolution, we are here to offer a different kind of investigation, one that may finally provide the answers you have been looking for.
1. What is reproductive immunology and how is it different from regular fertility treatment?
Reproductive immunology is a subspecialty that investigates how the immune system affects conception and pregnancy. Unlike standard fertility treatment, which focuses on hormones, ovulation, and embryo quality, reproductive immunology looks at whether the immune system is failing to tolerate a pregnancy, a cause that routine workups do not assess.
2. PCOS is common across India. Can it have an immune component?
Yes. PCOS is associated with chronic low-grade inflammation, which can affect the immune environment of the uterus and interfere with implantation. For women with PCOS who have experienced repeated IVF failure or recurrent miscarriage, an immune evaluation is clinically relevant.
3. I live in a smaller city not listed on ICPRM's network. Can I still access care?
Yes. Online consultations are available for patients across India, regardless of location. Based on the consultation, Dr. Raut can advise whether travel to one of our six centres is appropriate and help you plan your in-person visit.
4. Does ICPRM treat patients with no prior IVF experience?
Yes. While many of our patients have a history of IVF, we also see women who have not yet attempted IVF but are experiencing unexplained infertility or recurrent miscarriage. An immune evaluation can be useful regardless of prior treatment history.
5. How do I know if ImmuLIT is suitable for me?
Suitability for ImmuLIT is determined through our immune-focused evaluation. Not every patient requires it, and Dr. Raut will only recommend it when the investigation identifies immune dysfunction that the treatment can specifically address.
6. Is ICPRM's ImmuLIT treatment available outside India?
At present, ICPRM's treatment is available at our six centres within India. International patients can begin with an online consultation, and Dr. Raut can advise on whether travel to India for treatment is appropriate based on their case.
7. What is the success rate of ImmuLIT, and how is it measured?
ImmuLIT has been associated with a success rate of approximately 80% among patients treated at ICPRM. This reflects the proportion of treated patients who go on to achieve a successful pregnancy. Individual outcomes depend on a range of clinical factors, which Dr. Raut discusses transparently with each patient.

M.D.D.G.O, FCRI
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist

M.D., D.G.O., F.C.R.I.(ASRI)
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist