What Does Research Suggest About Unexplained Infertility and Egg Quality?
February 24, 2026
February 24, 2026

A positive pregnancy test followed by repeated miscarriages is becoming an increasingly common concern among couples in Hyderabad. But why does this happen even when everything appears “normal” in routine fertility reports? Specialists believe recurrent pregnancy loss is often linked to deeper underlying conditions that remain unnoticed until a detailed reproductive evaluation is performed.
In Hyderabad’s rapidly evolving urban lifestyle, factors such as delayed pregnancies, increasing PCOS cases, thyroid imbalance, chronic stress, poor sleep cycles, obesity, and autoimmune disorders are significantly affecting reproductive health. Many couples struggling with repeated miscarriages are now discovering hidden causes such as implantation failure, immune related pregnancy complications, genetic abnormalities, or blood clotting disorders that directly impact the body’s ability to sustain a pregnancy.
With advances in reproductive medicine, effective diagnosis and care are now possible. For those seeking the best recurrent pregnancy loss treatment in Hyderabad, expert assessment and personalized treatment plans can significantly improve outcomes. At ICPRM (Dr. Raut's Centre Of Reproductive Immunology), we offer specialized care that combines advanced diagnostics, compassionate support, and evidence-based therapies to help couples move forward with confidence and hope.
Recurrent Pregnancy Loss (RPL) is typically defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation. While miscarriage itself is common, occurring in nearly 10–15% of clinically recognized pregnancies, recurrent pregnancy loss affects a smaller percentage of couples, estimated at about 1–2%. Experiencing repeated losses can be both medically complex and emotionally overwhelming, often requiring specialized evaluation to identify underlying causes and improve the chances of a successful pregnancy.
Early detection of Recurrent Pregnancy Loss (RPL) is crucial for identifying the underlying causes and preventing further miscarriages. Factors that may contribute to RPL include hormonal imbalances, genetic abnormalities, uterine structural issues, thyroid disorders, and autoimmune conditions such as antiphospholipid syndrome.
When diagnosed at an early stage, doctors can begin timely investigations and provide targeted care, including hormonal support, blood-thinning medication, or corrective procedures. Early medical intervention improves the chances of a healthy pregnancy and reduces the emotional and physical stress caused by multiple losses.
By integrating evidence-based therapies with personalized care, ICPRM (Dr. Raut's Centre Of Reproductive Immunology) provides the best recurrent pregnancy loss treatment in hyderabad, helping couples improve reproductive outcomes and increase the chances of a healthy pregnancy while offering hope and confidence for the future.
Recurrent Pregnancy Loss (RPL) is becoming increasingly common among couples in Hyderabad, particularly due to changing urban lifestyles, work related stress, delayed pregnancies, and underlying reproductive health conditions.
Long working hours, night shifts, screen exposure, chronic stress, lack of physical activity, and irregular eating habits are increasingly affecting hormonal balance and reproductive health among couples in Hyderabad’s IT and corporate sectors. High stress levels can negatively impact ovulation, implantation, and overall pregnancy health.
Lack of exercise, prolonged sitting hours, unhealthy food habits, and rising obesity rates are contributing to metabolic disorders, insulin resistance, and poor reproductive health. Obesity is strongly linked to miscarriage risk, hormonal imbalance, and complications during early pregnancy. In some cases, no clear cause is identified despite thorough testing this is referred to as unexplained RPL.
At ICPRM (Dr. Raut's Centre Of Reproductive Immunology), we believe that every couple’s journey is unique. That is why our approach to recurrent pregnancy loss focuses on personalized treatment plans based on each patient’s medical history, diagnostic findings, and future family goals. We combine advanced reproductive science with compassionate care to provide clarity, confidence, and hope at every step, under the expert guidance of Dr. Mohan Raut and Dr. Mugdha Raut.
Lymphocyte Immunization Therapy (LIT) is the first immunomodulatory treatment used to treat unexplained recurrent miscarriage. It involves immunizing the prospective mother with allogenic mononuclear cells, mainly paternal or donor lymphocytes. Lymphocytes are key immune system cells and play an important role in rejection responses against immunologically different tissues.
Their use in LIT helps modulate the mother’s immune response toward the genetically different fetus. In nearly 50% of cases of repeated miscarriages and recurrent implantation failures (RIF), all investigations return normal results and are labeled as unexplained. A significant number of these unexplained RM/RIF cases are believed to result from allo-immune rejection due to a lack of protective blocking antibodies and T regulatory (Treg) cells.
A pregnancy contains 50% genetic material from the father and 50% from the mother, meaning the fetus carries paternal antigens that are foreign to the mother’s immune system. Logically, this could trigger an immune rejection response; however, in successful pregnancies, protective blocking antibodies and T regulatory cells prevent this rejection and allow the fetus to grow.
When these protective mechanisms fail to develop, reproductive failure may occur. LIT stimulates the production of blocking antibodies and T regulatory cells, thereby helping to prevent miscarriage and IVF failure. It is recommended for couples facing recurrent miscarriages, repeated IVF failures, and unexplained infertility, as it addresses underlying immunological factors and offers a targeted therapeutic approach toward achieving a successful pregnancy.
Treatment duration depends on the individual case and the specific therapy recommended. In general, most procedures are completed within a single visit.
If ImmuLIT® treatment is required, it is a one-time procedure that takes approximately 3 hours to complete. This includes preparation, the treatment itself, and post-treatment observation.
Choosing the right fertility center is crucial when dealing with recurrent pregnancy loss. At ICPRM, patients have access to strong expertise in obstetrics, gynecology, and reproductive medicine. Our doctors understand the medical complexity of RPL as well as the emotional sensitivity involved, ensuring comprehensive and compassionate care.
At ICPRM (Dr. Raut's Centre Of Reproductive Immunology), located at Apollo Fertility, Banjara Hills Road Number 3, Hyderabad – 500034, we offer personalized treatment strategies to each couple’s needs, including advanced therapies such as ImmuLIT®, designed to address immune-related causes of repeated miscarriages. Patients seeking the best recurrent pregnancy loss doctor in hyderabad benefit from expert assessment, ongoing support, and individualized care from specialists aimed at improving pregnancy outcomes and enhancing the chances of a healthy pregnancy.

M.D.D.G.O, FCRI
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist

M.D., D.G.O., F.C.R.I.(ASRI)
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist