What Does Research Suggest About Unexplained Infertility and Egg Quality?
August 1, 2025
August 1, 2025

Nagpur sits at the geographic heart of India, and its healthcare landscape is growing to match its size. But for many couples here, reproductive care has historically meant travelling to larger cities for anything beyond routine treatment. Awareness around conditions like recurrent miscarriage remains limited, and many women reach specialized fertility care only after experiencing multiple losses. By that point, they have often already gone through standard investigations and come back with reports that show nothing clearly wrong.
If that describes where you are right now, the issue may lie in what has not yet been investigated. At ICPRM, we focus on the immune-related causes of repeated pregnancy loss, the layer of the problem that routine fertility panels rarely assess. Our centre has the best recurrent pregnancy loss specialist in Nagpur, and our work is built around identifying immune dysfunction and addressing it with a treatment specifically designed for this purpose.
One factor that does not get enough attention in Central India is the role of reproductive tract infections. Untreated or inadequately treated infections can cause chronic pelvic inflammation that quietly interferes with implantation and early pregnancy. When gynecological care is delayed or inconsistent, these infections can persist long enough to affect the uterine environment in ways that increase the risk of miscarriage, sometimes repeatedly before anyone connects the two.
Nutritional health is another piece of the picture. Anemia and micronutrient deficiencies remain common among women in this region, and research has linked poor maternal nutrition to a range of pregnancy complications, including early pregnancy loss. When the body is already under nutritional stress, its ability to regulate inflammation and support a developing pregnancy is further compromised. These are not dramatic causes, but they are real and addressable ones that deserve to be part of any thorough miscarriage investigation.
Most people think of the immune system as something that fights illness. In pregnancy, it has to do something more nuanced: it has to tolerate the embryo even though that embryo carries the father's genetic material and is therefore partially foreign to the mother's body. When that tolerance does not develop properly, the immune system can respond to the embryo as a threat, and the pregnancy may not continue.
This mechanism is well-documented in recurrent miscarriage research but remains underdiagnosed in clinical practice. Studies on natural killer cell activity and inflammatory immune responses have found measurable irregularities in many patients with recurrent pregnancy loss. These irregularities do not appear on standard hormonal or genetic panels.
We do not function like a general IVF centre. At ICPRM, every case of repeated miscarriage is approached with a focused immune evaluation before any treatment is recommended. Dr. Mugdha Raut and Dr. Mohan Raut, both Consultant Gynaecologists and Clinical Reproductive Immunologists, review each patient's history specifically for signs of immune-related pregnancy failure. That means looking beyond chromosomes and hormones to understand what the immune system is actually doing during early pregnancy.
Our specialized treatment for this is ImmuLIT®, a patented Lymphocyte Immunization Therapy that works by using the father's prepared lymphocytes to help the maternal immune system build tolerance toward the pregnancy. It is an outpatient procedure completed in a single sitting of approximately three hours, with no hospitalization required. For couples where immune dysfunction has been identified as the likely cause of repeated loss, ImmuLIT® addresses the problem at its source. Among suitable candidates who complete the full protocol, we see an 80% success rate.
Our treatment pathway is structured to be clear and manageable for couples who have already been through a great deal.
Online Consultation: You share your miscarriage history and previous reports with us so we can review your case and assess whether immune causes may be involved.
Investigations: We conduct targeted immune testing, including NK cell activity and HLA cross-match, to identify specific irregularities that standard panels do not cover.
Single-Sitting 3-Hour ImmuLIT® Procedure: The immunotherapy is delivered in a single outpatient session of around three hours, with no overnight stay needed.
Follow-up: We monitor your pregnancy progress and provide immunological support through the early stages to track how your body is responding.
Parenthood: Our focus throughout is on improving the conditions for pregnancy continuation, giving each couple the best clinical foundation for a successful outcome.
Couples who come to us from Nagpur have usually already done what was recommended: the scans, the blood work, the genetic testing, sometimes IVF as well. What they have not had is an evaluation that looks specifically at immune function. That is the gap we fill. We are located at Cardion Hospital, Opposite Dinanath High School, Tikekar Road, Dhantoli, Nagpur, making us accessible for patients across the city and from surrounding regions of Central India.
For couples who cannot travel immediately, the process begins with an online consultation. This means you can have your case reviewed and discuss next steps before planning an in-person visit. The ImmuLIT® procedure itself is completed in a single sitting, which reduces the number of trips required significantly. As experienced miscarriage doctors in Nagpur, our entire clinical focus is on repeated pregnancy loss and immune-related fertility failure, not fertility treatment in general. That focus is what makes the difference for patients whose cases have not responded to anything they have already tried.
1. Can untreated infections contribute to repeated miscarriage?
Yes. Reproductive tract infections that are inadequately treated can lead to chronic pelvic inflammation, which affects the uterine environment and can interfere with implantation and early pregnancy. In regions where gynecological care is sometimes delayed, this is an important factor to investigate.
2. How many miscarriages are considered recurrent pregnancy loss?
Two or more consecutive pregnancy losses are generally classified as recurrent. At that point, a thorough investigation is appropriate rather than simply waiting to try again. Immune causes in particular are worth evaluating early, as they are often missed in standard workups.
3. Can immune system problems affect pregnancy continuation?
Yes. When the maternal immune system fails to develop tolerance toward the embryo, it can trigger a response that ends the pregnancy. This is a recognized cause of recurrent miscarriage and is distinct from chromosomal or hormonal causes.
4. What is tested during an immunological miscarriage evaluation?
We assess markers like natural killer cell activity, cytokine levels, and HLA cross-match between partners. These tests are specifically designed to identify immune dysfunction and are not part of routine miscarriage investigations.
5. Is ImmuLIT® recommended after IVF-related miscarriages?
It can be, depending on what the immune evaluation reveals. Couples who have experienced repeated miscarriage after IVF, particularly with good-quality embryos, are often found to have immune-related causes. ImmuLIT is considered after a thorough immune assessment confirms it is the appropriate course of treatment.
6. Can couples outside Nagpur consult ICPRM remotely?
Yes. Our process begins with an online consultation, which allows couples from outside Nagpur and from other parts of Central India to have their case reviewed before making the journey for in-person investigations or the ImmuLIT procedure.
7. Do all recurrent miscarriage patients require immunotherapy?
No. ImmuLIT is recommended specifically for patients where immune dysregulation has been identified through investigation. Not every case of repeated miscarriage has an immune cause, which is why we conduct a thorough evaluation first before recommending any treatment.

M.D.D.G.O, FCRI
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist

M.D., D.G.O., F.C.R.I.(ASRI)
Consultant Gynaecologist & Obstetrician
Clinical Reproductive Immunologist