Understanding LIT: A Simplified Guide To Lymphocyte Immunization Therapy

In a recent informative talk, Dr. Mohan Raut—a pioneering figure in reproductive immunology—shed light on Lymphocyte Immunization Therapy (ImmuLIT®), a treatment offered at his centers across Mumbai, Nagpur, Pune, and Kuwait. With over 25 years of experience, Dr. Raut has been using LIT to help couples suffering from recurrent IVF failures, repeated miscarriages, and unexplained infertility.

What IsImmuLIT®?

ImmuLIT® stands for Lymphocyte Immunization Therapy. It is an immunomodulatory infertility treatment designed for couples who, despite undergoing several fertility procedures, continue to face failures with no identifiable medical cause. These are categorized as “unexplained” cases.

LIT is primarily used for:

• Repeated unexplained miscarriages
  
• Recurrent IVF failures
  
• Unexplained infertility
  

The underlying cause in such cases is often the immunological rejection of pregnancy, making LIT a crucial therapeutic option.

Who NeedsImmuLIT®?

Dr. Raut emphasized that not every patient facing reproductive challenges qualifies for this therapy. Only those who show specific immunological indicators are considered. Several diagnostic tests are conducted, such as:

• Lymphocyte or HLA Cross Match to detect protective anti-paternal antibodies
  
• Measurement of natural killer (NK) cells and cytokines like TNF-alpha
  
• Endometrial biopsy to detect CD57 cells
  

These tests help determine whether the immune system is contributing to pregnancy failure and if LIT is the right intervention.

How IsImmuLIT® Performed?

It is a one-time non-operative procedure done in a clinic. Blood is drawn from the husband (or sometimes a donor) and brought to a specialized laboratory for lymphocyte isolation, which is later injected intradermally into the wife”s forearms. No anesthesia, no hospitalization, and no complicated post-procedure care are involved.

Dr. Raut also stressed that LIT stands for “lymphocyte immunotherapy,” which is not blood transfusion. The lymphocytes are isolated and used solely for creating an immunoreaction in the body, not for transfusing blood.

Safety And Efficacy

Over the years, LIT has proven to be an extremely safe procedure. Patients do not experience significant allergic reactions, autoimmune issues, or immunosuppression. Occasionally, minor rashes or itching may occur but are easily managed with routine medication.

When it comes to success rates, international studies and Dr. Raut’s own clinical data reveal that well-selected patients show success rates of 75% to 85%. At his center, the success rate exceeds 80%, particularly in cases labeled as “difficult to treat.”

Conclusion

Lymphocyte Immunization Therapy offers hope to many couples grappling with unexplained pregnancy losses or failed fertility attempts. This non-invasive treatment does not suppress immunity but rather modulates it to support successful conception and pregnancy.

Couples struggling with infertility can benefit greatly from consulting a fertility specialist to determine whether they are suitable candidates for LIT. For women facing challenges, exploring female infertility treatment options like LIT could be a turning point in their journey to parenthood.To learn more about ImmuLIT® or schedule a consultation, visit Dr. Raut’s Centre for Reproductive Immunology’sofficial website.