
What is ImmuLIT® and how is it different from regular LIT (Lymphocyte Immunization Therapy)?
November 7, 2025
For many couples struggling with recurrent miscarriages, unexplained infertility, or IVF failure, the cause often lies in the body’s immune response. When a woman’s immune system reacts against the partner’s genetic material during conception, it may prevent successful implantation or trigger repeated miscarriages. This is where Lymphocyte Immunization Therapy (LIT) and its advanced version, ImmuLIT®, play a crucial role.
At ICPRM, under the expert guidance of Dr. Mugdha Raut and Dr. Mohan Raut, immunotherapy has been refined and optimized to offer better precision, safety, and success in improving pregnancy outcomes.
Understanding Lymphocyte Immunization Therapy (LIT)
Lymphocyte Immunization Therapy (LIT) is an established immunotherapy for infertility and recurrent miscarriage treatment. The procedure involves using the male partner’s white blood cells (lymphocytes) to help the woman’s immune system recognize and accept the paternal antigens. This builds what’s known as “blocking antibodies,” which protect the pregnancy from being attacked as a foreign body.
Key Benefits of LIT:
- Reduces immune rejection of the embryo
- Increases tolerance towards paternal antigens
- Enhances chances of implantation after IVF or natural conception
- Supports women with allo-immune miscarriage or unexplained infertility
However, while LIT has shown promising results, its effectiveness depends on the purity, viability, and preparation technique of the lymphocyte sample. This is where ImmuLIT® stands out.
What is ImmuLIT®?
ImmuLIT® is an advanced version of Lymphocyte Immunization Therapy, developed and standardized at ICPRM by Dr. Mugdha Raut and Dr. Mohan Raut after years of clinical experience in reproductive immunology.
ImmuLIT® uses a refined, sterile, and optimized preparation of lymphocytes, ensuring better immune modulation and higher therapeutic consistency. This enhancement not only improves safety but also increases the lymphocyte immunization therapy success rate in women with repeated implantation failures or miscarriages.
Difference Between ImmuLIT® and Regular LIT
Feature | Regular LIT (Lymphocyte Immunization Therapy) | ImmuLIT®(Advanced LIT at ICPRM) |
Technique | Conventional method using partner’s lymphocytes | Advanced, standardized, and purified immunotherapy developed at ICPRM |
Processing | Basic isolation of lymphocytes | Refined and quality-controlled preparation ensuring higher cell viability |
Safety Protocols | General sterilization practices | Stringent sterile processing with enhanced biosafety and biocompatibility standards |
Immune Modulation | Induces immune tolerance through blocking antibodies | Enhanced modulation of immune response, leading to improved embryo acceptance |
Efficacy in Recurrent Miscarriage | Effective but varies case-to-case | Demonstrated higher success rates in recurrent miscarriage treatment |
Effect on IVF and Infertility | Supports implantation but may require repetition | More consistent outcomes in IVF failure and unexplained infertility treatment |
Patient Experience | Multiple sessions may be needed | Optimized protocol requiring a single session with better comfort |
Developed By | Conventional immunotherapy methods | Innovated by Dr. Mugdha Raut and Dr. Mohan Raut at ICPRM |
How ImmuLIT® Works in Infertility and Recurrent Miscarriage Treatment
The ImmuLIT® process involves collecting the male partner’s blood, processing lymphocytes in a sterile environment, and injecting them intradermally into the female partner. This helps “educate” the immune system to tolerate the paternal genetic material during conception.
By promoting immune tolerance, ImmuLIT® supports:
- Successful implantation after failed IVF cycles
- Treatment after miscarriage to prevent recurrence
- Allo-immune miscarriage treatment by balancing immune responses
- Unexplained infertility treatment through improved embryo-maternal interaction
This targeted immunotherapy for infertility works in synergy with fertility treatments, helping many couples achieve successful pregnancies after multiple failures.
Why Choose ImmuLIT® at ICPRM?
At ICPRM, the ImmuLIT® procedure is conducted by a highly experienced team of reproductive immunology specialists with over two decades of clinical expertise. The center integrates advanced laboratory infrastructure with rigorous safety and quality protocols to ensure the highest level of precision and sterility in every stage of treatment. Each ImmuLIT® plan is customized according to the couple’s specific immune profile, allowing for a targeted therapeutic approach that enhances both safety and clinical outcomes.
Led by Dr. Mugdha Raut and Dr. Mohan Raut, ICPRM has consistently demonstrated success in addressing complex cases such as failed pregnancies, missed miscarriage treatment, and IVF failure. Their continued innovation in reproductive immunotherapy has established ICPRM as a leader in evidence-based, result-driven fertility care, committed to improving pregnancy success rates through scientific excellence and personalized patient management.
Final Thoughts
ImmuLIT® marks a significant advancement in the field of Lymphocyte Immunization Therapy, offering superior safety, precision, and efficacy for couples struggling with recurrent miscarriages or unexplained infertility. By integrating refined immunological techniques with advanced reproductive medicine, ImmuLIT® enhances the body’s natural tolerance mechanisms, paving the way for more consistent and successful pregnancy outcomes. It stands as a scientifically validated, patient-focused approach that transforms how immune-related infertility is managed.
For couples who have experienced failed pregnancies or multiple IVF failures, ICPRM provides a comprehensive evaluation to determine if ImmuLIT® is the most suitable course of treatment. Under the expertise of Dr. Mugdha Raut and Dr. Mohan Raut, patients receive personalized guidance rooted in evidence-based care and clinical precision, offering renewed hope and a stronger possibility of achieving a healthy, full-term pregnancy.