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ICPRM

ICPRM

It is the first center established in India to provide specialized treatment to patients suffering from Repeated Miscarriages, IVF failures & Uexplained Infertility using LIT & other immunomodulation treatment. It provides complete diagnostic set up & comprehensive treatment.

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Dr. Mugdha Raul, MD

Dr. Mugdha Raul, MD

Dr. Mugdha Raul, MD, DGO received her medical degree (Graduation & Post Graduation) from the premier institute Seth G.S Medical College & KEM Hospital, Mumbai. She was trained in Infertility under Dr. Mehroo Honsotia at Nowrosjee Wadia Maternity Hospital, Mumbai. She was a gold-medalist in her graduation programme. Dr. Mugdha was associated with Dr. Usha Krishna at the K.E.M. Hospital for her work in the field of Repeated Miscarriages & BOH (Bad Obstretric History).

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Dr. Mohan Raut, MD

Dr. Mohan Raut, MD

Dr. Mohan Raut MD, DGO received his degree(Graduation & Post Graduation) from the premier institute Seth G.S Medical College & KEM Hospital, Mumbai.

In 1992, Dr. Mohan Raut was a part of International Multicentric Research Programme in association with Oxford University on the role of Active lmmunotherapy in Recurrent Miscarriages. Later, he had been involved in the Active lmmunotheapy Programme (LIT Therapy) at H.N. Hospital, Mumbai under the guidance of Dr. Usha Krishna. He has contributed a chapter on lmmunotherapy in Repeated Miscarriages in the book ‘Pregnancy At Risk-Current Concepts’ published by FOGSI.

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What is LIT?

Lymphocyte Immunization Therapy (LIT) It is an immunomodulatory treatment used in the management of Unexplained Repeated Miscarriages, Recurrent IVF Failures & Unexplained Infertility.

It involves separation of Lymphocytes (a Special type of white blood cells required for Immunological function) from husband’s blood and injecting them into wife. This is done before the woman conceives so that it can prevent subsequent miscarriages or IVF failures.

Why LIT?

When there is a pregnancy, 50% of it is from the father, that is immunologically foreign to the mother’s body, but surprisingly, pregnancy is not rejected. This is because the pregnancy is protected by certain immunological mechanisms which prevent the rejection. Unfortunately, in some women these mechanisms are disturbed and hence, when there is conception, mother’s body develops immunological reaction against the pregnancy, leading to repeated miscarriage or IVF failures. LIT helps to overcome this problem by causing immunomodulation.

When LIT?

Lymphocyte immunization Therapy holds much potential as a safe and effective treatment approach for patients who have failed IVF or repeated miscarriages.

Selection of a couple for LIT Therapy depends on many factors. This involves detailed history, investigations to rule out known causes of RM/IVF failures and certain specific investigations to t identify allo-immune factor.

IVF Failure & LIT

In Vitro Fertilization (IVF)has a success rate of 40% inspite of the advances in the field. Recurrent IVF Failure affects 10% of all patients undergoing IVF and many of them are unexplained. These cases can be due to immunological rejection of pregnancy and immunomodulation using LIT can help to overcome this problem.

LIT Benefits

  • High Success Ratio
  • No Long Term Side Effects
  • Easy Treatment
  • Safe Procedure
  • Single Seating
  • Researched & Patented Technology

Repeated Miscarriages & LIT

It has been estimated that 1-2% of all the women suffer from the problem of repeated miscarriages. As the number of miscarriages increase, the chance of a miscarriage in the subsequent pregnancy increases. 50-60% of these cases are unexplained and can be due to immunological rejection of pregnancy. These cases can be effectively treated by immunomodulation using LIT.

LIT Therapy

Features

Benefits

Success Ratio

Side Effects

Features
  • LIT involves separation of lymphocytes from husband’s blood and injecting them in the wife
  • LIT is an out patient procedure
  • After LIT, the couple is asked to make active attempts at conception after a period of 4-6 weeks
  • The woman should conceive within one year after LIT for optimum results
  • LIT is free from major side effects.
Benefits
  • High Success Ratio
  • No Long Term Side Effects
  • Easy Treatment
  • Safe Procedure
  • Single Seating
  • Researched & Patented Technology
Success Ratio

Total of 596 couples were given Immunotherapy, 486 patients with Recurrent Miscarriages or unexplained infertility and 110 patients with IVF
implantation failure. Of the 486 with RM, 390 women conceived and delivered live fetus at 33 weeks or later. Of the 110 patients with IVF failure 85 conceived & delivered at 33 weeks or later.

Side Effects

As LIT involves separation and injection of blood component (lymphocytes), establishing complete safety is important.

1
Patent
54
Years Experience
83%
Success Rate
609
LTI Treatments

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